Publications / Citations


Ischemia time monitoring: Experience of the Prostate Cancer Biorepository Network. Pe Benito R, Fedor H, Gorman M, Netto G, Sfanos KS, Kolmer P, Darshan M, Morgan J, Lee P, De Marzo AM, Trock BJ, Melamed JM. ISBER 2012 Annual Meeting & Exhibits. May 15-18 2012. Vancouver, British Columbia, Canada.
The Prostate Cancer Biospecimen Network (PCBN) Pe Benito R, Fedor H, Gorman M, Netto G, Sfanos KS, Kolmer P, Darshan M, Morgan J, Lee P, De Marzo AM, Trock BJ, Melamed JM. ISBER 2012 Annual Meeting & Exhibits. May 15-18 2012. Vancouver, British Columbia, Canada.
Prostate Cancer Biorepository (Flyer). 2012 AACR Annual Meeting. March 31-April 4 2012. Chicago, IL.
Biobanking as Part of the Prostate Cancer Biorepository Network (PCBN): A focus on DNA, RNA and Protein Derivative from Radical Prostatectomy Specimens. Darshan M, Fedor H, Zheng Q, Kolmer P, Pe Benito R, Gorman M, Lee P, Melamed JM, Trock BJ, De Marzo AM, Sfanos KS. OBBR BRN Symposium. February 22-23 2012
Ischemia / Fixation Trial Tissue Microarray. Pe Benito R, Fedor H, Gorman M, Netto G, Sfanos KS, Kolmer P, Darshan M, Morgan J, Lee P, De Marzo AM, Trock BJ, Melamed JM. OBBR BRN Symposium. February 22-23 2012
Prostate Cancer Biorepository Network: Prostate Cancer Specimens for Your Research (Flyer). CDMRP IMPaCT 2011 Conference. March 9-12 2011. Orlando, FL.
The Prostate Cancer Biorepository Network (PCBN). CDMRP IMPaCT 2011 Conference. March 9-12 2011. Orlando, FL.
Biobanking of Derivatives from Radical Retropubic and Robot−Assisted Laparoscopic Prostatectomy Tissues as part of the Prostate Cancer Biorepository Network (PCBN) Society for Basic Urological Research (SBUR) Meeting. November 15-18, 2012. Miami, FL
Biobanking of Derivatives from Radical Retropubic and Robot-Assisted Laparoscopic Prostatectomy Tissues as Part of the Prostate Cancer Biorepository Network Darshan M, Zheng Q, Fedor HL, Wyhs N, Yegnasubramanian S, Lee P, Melamed J, Netto GJ, Trock BJ, De Marzo AM, Sfanos KS. Prostate. 2014 Jan;74(1):61-9. doi: 10.1002/pros.22730. Epub 2013 Sep 21.
Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides Baena-Del Valle J , Zheng Q, Hicks J, Fedor H, Trock B, Morrissey C, Core E, Cornish TC, Sfanos KS, De Marzo AM. American Journal of Clinical Pathology; doi: 10.1093

Studies Utilizing the PCBN Resource

MYC Targeted Long Non-Coding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels. Lu Y, Hu Z, Mangala KS, Stine ZE, Hu X, Jiang D, Xiang Y, Zhang Y, Pradeep S, Rodriguez-Aguayo C, Lopez-Berestein G, DeMarzo A, Sood AK, Zhang L, Dang CV. Cancer Research; doi: 10.1158
Arylsulfatase B is Reduced in Prostate Cancer Recurrences.Feferman L, Deaton R, Bhattacharyya S, Xie H, Gann PH, Melamed J, Tobacman JK. IOS Press Content Library; doi: 10.3233
Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development Lee JH, Yang B, Lindahl AJ, Damaschke N, Boersma MD, Huang W, Corey E, Jarrard DF, Denu JM. ACS; doi: 10.1021
DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor Jing Y, Nguyen MM, Wang D, Pascal LE, Guo W, Xu Y, Ai J, Deng FM, Masoodi KZ, Yu X, Zhang J, Nelson JB, Xia S and Wang Z. Oncogene; doi: 10.1038
Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate W. Nathaniel Brennen, Baohui Zhang, Ibrahim Kulac, L. Nelleke Kisteman, Lizamma Antony, Hao Wang, Alan K. Meeker, Angelo M. De Marzo, Isla P. Garraway, Samuel R. Denmeade, John T. Issacs Oncotarget; doi: 10.18632
Automated analysis of co-localized protein expression in histologic sections of prostate cancer Thomas A. Tennill, Mitchell E. Gross, Hermann D. Frieboes PLOS One, May 2017; doi: 10.371
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations Franklin W. Huang, Juan Miguel Mosquera, Andrea Garofalo, Coyin Oh, Maria Baco, Ali Amin-Mansour, Bokang Rabasha, Samira Bahl, Stephanie A. Mullane, Brian D. Robinson, Saud Aldubayan, Francesca Khani, Beerinder Karir, Eejung Kim, Jeremy Chimene-Weiss, Matan Hofree, Alessandro Romanel, Joseph R. Osborne, Jong Wook Kim, Gissou Azabdaftari, Anna Woloszynska-Read, Karen Sfanos, Angelo M. De Marzo, Francesca Demichelis, Stacey Gabriel, Eliezer M. Van Allen, Jill Mesirov, Pablo Tamayo, Mark A. Rubin, Isaac J. Powell, and Levi A. Garraway Cancer Discovery, May 2017; doi: 10.1158/2159-8290.CD-16-0960
Differential Long-Term Stability of microRNAs and RNU6B snRNA in 12-20 Year Old Archived Formalin-Fixed Paraffin-Embedded Specimens Sarah B. Peskoe, John R. Barber, Qizhi Zheng, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz and Shawn E. Lupold BMC Cancer, January 2017; doi: 10.1186/s12885-016-3008-4
Low Intratumoral Mast Cells are Associated with a Higher Risk of Prostate Cancer Recurrence Heidi A Hemple, Nathan S Cuka, Ibrahim Kulac, John R Barber, Toby C Cornish, Elizabeth A Platz, Angelo M De Marzo, Karen S Sfanos. The Prostate, March 2017; doi: 10.1002/pros.23280
α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of
the Hippo Pathway
Afshin Varzavand, Will Hacker, Deqin Ma, Katherine Gibson-Corley, Maria Hawayek, Omar J. Tayh, James A. Brown, Michael D. Henry and Christopher S. Stipp Cancer Research, September 2016; doi: 10.1158/0008-5472.CAN-16-1483
Prediction of Prostate Cancer Recurrence using Quantitative Phase Imaging: Validation on a General Population Shamira Sridharan, Virgilia Macias, Krishnarao Tangella, Jonathan Melamed, Emily Dube, Max Xiangtian King, Andre Kajdacsy-Balla and Gabriel Popescu Scientific Reports, September 2016; 6: 33818. doi: 10.1038/srep33818
Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer Liana B. Guedes, Carlos L. Morais, Fawaz Almutairi, Michael C. Haffner, Qizhi Zheng, John T. Issacs, Emmanuel S. Antonarakis, Changxue Lu, Harrison Tsai, Jun Lup, Angelo M. De Marzo, and Tamara L. Lotan Clinical Cancer Research, September 2016; DOI: 10.1158/1078-0432.CCR-16-0205
Identification of miR-30b-5p as Direct Regulators of Androgen Receptor Signaling in Prostate Cancer by Complementary Functional microRNA Library Screening Binod Kumar, Salar Khalenghzadegan, Brian Mears, Koji Hatano, Tarana A. Kudrolli, Wasim H. Chowdhury, David B. Yeater, Charles M. Ewing, Jun Luo, William B. Issacs, Luigi Marchionni and Shawn E. Lupold Oncotarget, September 2016; doi: 10.1158/0008-5472.CAN-16-1483
A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Shu-Han Yu, Qizhi Zheng, David Esopi, Anne Macgregor-Das, Jun Luo, Emmanuel S. Antonarakis, Charles G. Drake, Robert Vessella, Colm Morrissey, Angelo M. De Marzo, and Karen S. Sfanos Cancer Immunology Research, October 2015; 3(10):1175–84. doi: 10.1158/2326-6066.CIR-15-0013
Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment and are Differentially Associated with Metastatic Prostate Cancer Paula J. Hurley, Debasish Sundi, Brian Shinder, Brian W. Simons, Robert M. Hughes, Rebecca M. Miller, Benjamin Benzon, Sheila F. Faraj, George J. Netto, Ismael A. Vergara, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Guifang Yan, Charles Ewing, Sarah D. Isaacs, David M. Berman, Jennifer R. Rider, Kristina M. Jordahl, Lorelei A. Mucci, Jessie Huang, Steven S. An, Ben H. Park, William B. Isaacs, Luigi Marchionni, Ashley E. Ross, and Edward M. Schaeffer Clinical Cancer Research, Oct 7, 2015. doi: 10.1158/1078-0432.CCR-15-0256
A Novel Quantitative Multiplex Tissue Immunoblotting for Biomarkers Predicts a Prostate Cancer Aggressive Phenotype Guangjing Zhu, Zhi Liu, Jonathan I. Epstein, Christine Davis, Christhunesa S. Christudass, H. Ballentine Carter, Patricia Landis, Hui Zhang, Joon-Yong Chung, Stephen M. Hewitt, M. Craig Miller, and Robert W. Veltri Cancer Epidemiol Biomarkers Prev., Sept 24, 2015; 24(12):1864-72. doi: 10.1158/1055-9965.EPI-15-0496
Molecular Evidence That Invasive Adenocarcinoma Can Mimic Prostatic Intraepithelial Neoplasia (PIN) and Intraductal Carcinoma Through Retrograde Glandular Colonization Michael C. Haffner, Christopher Weier, MengMeng Xu, Ajay Vaghasia, Bora Gürel, Berrak Gümüşkaya, David M. Esopi, Helen Fedor, Hsueh-Li Tan, Ibrahim Kulac, Jessica Hicks, William B. Isaacs, Tamara L. Lotan, William G. Nelson, Srinivasan Yegnasubramanian, Angelo M. De Marzo The Journal of Pathology, Aug 31, 2015; 238(1):31–41. doi: 10.1002/path.4628
Overexpression of Periostin in Stroma Positively Associated with Aggressive Prostate Cancer Yuan Tian, Caitlin H. Choi, Qing Kay Li, Farah B. Rahmatpanah, Xin Chen, Sara Ruth Kim, Robert Veltri, David Chia, Zhen Zhang, Dan Mercola, Hui Zhang PLoS One, June 4, 2015; 10(6):e0130333. doi: 10.1371/journal.pone.0130333
A Gold Nanoparticle-Enabled Blood Test for Early Stage Cancer Detection and Risk Assessment Tianyu Zheng, Nickisha Pierre-Pierre, Xin Yan, Qun Huo, Alvin Almodovar, Felipe Valerio, Inoel Rivera-Ramirez, Elizabeth Griffith, David D Decker, Sixue Chen, and Ning Zhu ACS Appl. Mater. Inter., March 10th 2015; 7(12):6819-27. doi: 10.1021/acsami.5b00371
The Hippo Pathway Effector, YAP, Regulates Motility, Invasion and Castration- Resistant Growth of Prostate Cancer Cells Lin Zhang, Shuping Yang, Xingcheng Chen, Seth Stauffer, Fang Yu,Subodh M. Lele, Kai Fu, Kaustubh Datta, Nicholas Palermo, Yuanhong Chen, and Jixin Dong Mol. Cell. Biol., Feb 2015; 35(8):1350-62. doi:10.1128/MCB.00102-15
LEF1 Targeting EMT in Prostate Cancer Invasion is Mediated by miR-181a Jiaqian Liang, Yirong Li, Garrett Daniels, Karen Sfanos, Angelo De Marzo, Jianjun Wei, Xin Li, Wenqiang Chen, Jinhua Wang, Xuelin Zhong, Jonathan Melamed, Jun Zhao, and Peng Lee
Molecular Cancer Research, January 13, 2015; 5(3):1124-32. doi:10.1158/1541-7786.MCR-14-0503
Investigation of miR-21, miR-141, and miR-221 Expression Levels in Prostate Adenocarcinoma for Associated Risk of Recurrence After Radical Prostatectomy Qizhi Zheng, Sarah B. Peskoe, Judit Ribas, Fatema Rafiqi, Tarana Kudrolli, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz, and Shawn E. Lupold Prostate, Dec 2014; 74(16):1655-62. doi: 10.1002/pros.22883
Tumour-infiltrating Gr-11 Myeloid Cells Antagonize Senescence in Cancer Diletta Di Mitri, Alberto Toso, Jing Jing Chen, Manuela Sarti, Sandra Pinton, Tanja Rezzonico Jost, Rocco D’Antuono, Erica Montani, Ramon Garcia-Escudero, Ilaria Guccini, Sabela Da Silva-Alvarez, Manuel Collado, Mario Eisenberger, Zhe Zhang, Carlo Catapano, Fabio Grassi and Andrea Alimonti Nature, 2014 Nov 6; 515(7525):134-137. doi: 10.1038/nature13638
AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer Emmanuel S. Antonarakis, Changxue Lu, Hao Wang, Brandon Luber, Mary Nakazawa, Jeffrey C. Roeser, Yan Chen, Tabrez A. Mohammad, Yidong Chen, Helen L. Fedor, Tamara L. Lotan, Qizhi Zheng, Angelo M. De Marzo, John T. Isaacs, William B. Isaacs, Rosa Nadal, Channing J. Paller, Samuel R. Denmeade, Michael A. Carducci, Mario A. Eisenberger, and Jun Luo N. Engl. J. Med., Sep 2014; 371:1028-1038. doi: 10.1056/NEJMoa1315815
AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis JuanJuan Yin, Yen-Nien Liu, Heather Tillman, Ben Barrett, Stephen Hewitt, Kris Ylaya, Lei Fang, Ross Lake, Eva Corey, Colm Morrissey, Robert Vessella, and Kathleen Kelly Cancer Res., Aug 2014; 74: 4306 - 4317. doi: 10.1158/0008-5472.CAN-13-3233
Hepatocyte Growth Factor-Like Protein is Required for Prostate Tumor Growth in the TRAMP Mouse Model Vasiliauskas J, Nashu MA, Pathrose P, Starnes SL, Waltz SE Oncotarget., 2014 Jul 30; 5(14):5547-58.
USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression Randy S. Schrecengost, Jeffry L. Dean, Jonathan F. Goodwin, Matthew J. Schiewer, Mark W. Urban, Timothy J. Stanek, Robyn T. Sussman, Jessica L. Hicks, Ruth C. Birbe, Rossitza A. Draganova-Tacheva, Tapio Visakorpi, Angelo M. De Marzo, Steven B. McMahon, and Karen E. Knudsen Cancer Res., Jan 2014; 74: 272 - 286. doi: 10.1158/0008-5472.CAN-13-1954
TBLR1 as an Androgen Receptor (AR) Coactivator Selectively Activates AR Target Genes to Inhibit Prostate Cancer Growth Garrett Daniels, Yirong Li, Lan Lin Gellert, Albert Zhou, Jonathan Melamed, Xinyu Wu, Xinming Zhang, David Zhang, Daniel Meruelo, Susan K Logan, Ross Basch, and Peng Lee Endocr. Relat. Cancer, Jan 2014; 21:127-142. doi: 10.1530/ERC-13-0293
Tracking the Clonal Origin of Lethal Prostate Cancer Michael C. Haffner, Timothy Mosbruger, David M. Esopi, Helen Fedor, Christopher M. Heaphy, David A. Walker, Nkosi Adejola, Meltem Gürel, Jessica Hicks, Alan K. Meeker, Marc K. Halushka, Jonathan W. Simons, William B. Isaacs, Angelo M. De Marzo, William G. Nelson and Srinivasan Yegnasubramanian J. Clin. Invest., Nov 2013; 123(11):4918–4922. doi: 10.1172/JCI70354
Phosphorylation of the Androgen Receptor by PIM1 in Hormone Refractory Prostate Cancer S Ha, N J Iqbal, P Mita, R Ruoff, W L Gerald, H Lepor, S S Taneja, P Lee, J Melamed, M J Garabedian and S K Logan Oncogene, Sep 2013; 32(34):3992-4000. doi: 10.1038/onc.2012.412
Secreted Protein, Acidic and Rich in Cysteine-Like 1 (SPARCL1) is Down Regulated in Aggressive Prostate Cancers and is Prognostic for Poor Clinical Outcome Paula J. Hurley, Luigi Marchionni, Brian W. Simons, Ashley E. Ross, Sarah B. Peskoe, Rebecca M. Miller, Nicholas Erho, Ismael A. Vergara, Mercedeh Ghadessi, Zhenhua Huang, Bora Gurel, Ben Ho Park, Elai Davicioni, Robert B. Jenkins, Elizabeth A. Platz, David M. Berman, and Edward M. Schaeffer PNAS, Sep 2012; 109:14977-14982. doi: 10.1073/pnas.1203525109
Regulation of a Novel Androgen Receptor Target Gene, the Cyclin B1 Gene, Through Androgen-Dependent E2F Family Member Switching Yirong Li, David Y. Zhang, Qinghu Ren, Fei Ye, Xin Zhao, Garrett Daniels, Xinyu Wu, Brian Dynlacht, and Peng Lee Mol. Cell. Biol., Jul 2012; 32:2454-2466. doi: 10.1128/MCB.06663-11